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finding:transient-bioelectrical-modulation-of-body-wide-pattern-memory-circuits-in-planaria-can-shift-them-from-one-headed-to-persistent-two-headed-state-persisting-through-amputation-rounds-until-reset-with-different-manipulation

Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.

Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.

Source paper

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The collective intelligence of evolution and development

(2023) · Watson, Richard · Levin, Michael

Neighborhood — ranked by edge-count

Claims (3)

claim

Bioelectricity serves as a ‘cognitive glue’ common to collective and individual intelligence, binding cells into competent individuals in both behaviour and morphogenetic spaces.
supports
Identifies bioelectric networks as the medium of basal cognition.
If intercellular signalling (not genes) is the cognitive medium of a morphogenetic individual, it should be possible to exploit tools of neuroscience to read, interpret and re-write its information content for predictive control.
supports
Strong prediction from basal cognition framework; validated in planaria and other species through bioelectric manipulation.
Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.
supports
Highlights the non-genetic control of large-scale anatomy.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.finding0.906
Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.
Bioelectric signatures control morphogenetic target patterns; transient bioelectrical modulation in planaria produces persistent two-headed phenotype.finding0.885
Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.881
Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.
Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).finding0.876
Shows reversibility of bioelectric pattern memory.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.867
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
Pattern memory in planaria can be re-written non-genetically via transient modification of membrane potential, leading to permanent changes in target morphology.claim0.852
Summarizes the two-headed planarian phenomenon.
Planarian bioelectric circuits can enter a metastable cryptic state where they stochastically produce one- or two-headed worms upon each amputation, analogous to perceptual bistability.claim0.847
Links cognitive and morphogenetic dynamics.
Planarian pattern memory is encoded in bioelectric attractor states within gap-junction-coupled networks, which can be re-written by channel modulation.hypothesis0.847
Testable by computational modeling and experimental perturbation of specific bioelectric circuits.

Cross-corpus bridges (1)

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Can pattern memories encoded in bioelectric states persist through radical morphological reorganization during regeneration?questions/can-pattern-memories-encoded-in-bioelectric-states-persist.md0.817