Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.

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• The large-scale morphological goals of an organism override and harness the local competencies of individual cells to adaptively navigate morphospace.claim0.843
  Describes top-down control in morphogenesis.
• When a subset of cells is given a morphogenetic goal (e.g., build an eye), they autonomously recruit unmodified neighbors to complete the structure, showing modular competency.claim0.826
  Principle of top-down control.
• Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.claim0.822
• Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.807
  Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
• What mechanisms allow coordination of cell activity toward one consistent morphology?question0.804
  Foundational question driving investigation into how homeostatic capabilities of cells scale to collective setpoints.
• The larger task of making these processes genuinely morphogenetic so that they generate deeper and more coherent living structure—still lies on the horizon.claim0.797
• Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.796
  Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
• The formation of centers is guided by generic patterns which play the role of genes.claim0.794
  Analogy to biology, placing pattern languages as the genetic code for living built environments.