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finding:bioelectrical-modulation-can-revert-two-headed-planaria-back-to-normal-durant-et-al-2017

Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).

Shows reversibility of bioelectric pattern memory.

Source paper

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The collective intelligence of evolution and development

(2023) · Watson, Richard · Levin, Michael

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Claims (1)

claim

Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.
supports
Highlights the non-genetic control of large-scale anatomy.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.876
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.855
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedfinding0.848
Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.
Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.846
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.finding0.844
Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.
Two-headed planaria via bioelectric circuit modificationfinding0.840
Bioelectric signatures control morphogenetic target patterns; transient bioelectrical modulation in planaria produces persistent two-headed phenotype.finding0.833
Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.832
Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.