finding

active

finding:bioelectric-perturbation-permanently-alters-planarian-head-number-to-two-headed-or-zero-headed

Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headed

Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

Neighborhood — ranked by edge-count

Claims (1)

claim

Bioelectric pattern memories are a re-writable information medium that stores target morphology without genomic change.
supports
Asserts that evolution exploits a software-like layer for anatomical form, enabling rapid morphological change.

Communities (3)

community

Bioelectric memory & morphogenetic identity
members_of
Gap junctions and bioelectric signals encode body-plan and memory patterns across radical biological transformation.
Bioelectric control of planarian morphogenesis
members_of
Transient bioelectric manipulation persistently alters head number and patterning despite wild-type genetics in planaria.
Bioelectric control of planarian head patterning
members_of
Experimental manipulation of resting membrane potential patterns to stably alter morphogenesis (head number/location) independent of genetic sequence, primarily in Dugesia species 2011-2017.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Permanent two-headed planarians created by manipulating bioelectric circuits.finding0.855
From Oviedo et al. (2010) and Durant et al. (2017), shows memory of anatomical set points beyond genomic default.
Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).finding0.848
Shows reversibility of bioelectric pattern memory.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.830
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
In planaria, the most depolarized region becomes the head; altering bioelectric pattern changes head location and number (Beane et al. 2011, Durant et al. 2017)finding0.828
The collective interprets relative voltage differences, not absolute values, to decide anterior identity.
Two-headed planaria via bioelectric circuit modificationfinding0.826
Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.finding0.823
Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.
Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.823
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Planarian bioelectric circuits can enter a metastable cryptic state where they stochastically produce one- or two-headed worms upon each amputation, analogous to perceptual bistability.claim0.821
Links cognitive and morphogenetic dynamics.