Two-headed planaria via bioelectric circuit modification

Source paper

extracted_from

Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind

(2023) · Levin, Michael

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Concepts (1)

concept

Morphogenetic Memory
supports
Bioelectric pattern memory encoding target morphologies; can be modified by experience and persists across regeneration cycles; functional analog of behavioral memory.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Permanent two-headed planarians created by manipulating bioelectric circuits.finding0.881
From Oviedo et al. (2010) and Durant et al. (2017), shows memory of anatomical set points beyond genomic default.
Planarian Two-Headed Regeneration via Bioelectric Circuit Rewritingfinding0.874
Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.859
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
Bioelectric Head Patterning in Planariafinding0.847
Bioelectric gradients regionalize gene expression to determine head structure in planaria; system can be hijacked by microbes to control host head number and morphology.
Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).finding0.840
Shows reversibility of bioelectric pattern memory.
Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.834
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Planaria permanently generate two-headed forms despite completely wild-type genetic sequence after bioelectric pattern rewriting.finding0.826
Demonstrates that anatomical outcomes can be reprogrammed at the bioelectric level independently of DNA, inverting the software/hardware metaphor
Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedfinding0.826
Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.