finding

active

finding:permanent-two-headed-planarians-created-by-manipulating-bioelectric-circuits

Permanent two-headed planarians created by manipulating bioelectric circuits.

From Oviedo et al. (2010) and Durant et al. (2017), shows memory of anatomical set points beyond genomic default.

Source paper

extracted_from

Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms

(2023) · Clawson, Wesley P. · Levin, Michael

Neighborhood — ranked by edge-count

Claims (1)

claim

Xenobots’ anatomical and behavioral goals are emergent, rather than directly selected over aeons.
supports
Argues that goal states arise without direct evolutionary sculpting.

Communities (3)

community

Bioelectric memory & morphogenetic identity
members_of
Gap junctions and bioelectric signals encode body-plan and memory patterns across radical biological transformation.
Bioelectric control of planarian morphogenesis
members_of
Transient bioelectric manipulation persistently alters head number and patterning despite wild-type genetics in planaria.
Bioelectric control of planarian head patterning
members_of
Experimental manipulation of resting membrane potential patterns to stably alter morphogenesis (head number/location) independent of genetic sequence, primarily in Dugesia species 2011-2017.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Two-headed planaria via bioelectric circuit modificationfinding0.881
Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedfinding0.855
Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.
Planarian Two-Headed Regeneration via Bioelectric Circuit Rewritingfinding0.850
Planaria permanently generate two-headed forms despite completely wild-type genetic sequence after bioelectric pattern rewriting.finding0.845
Demonstrates that anatomical outcomes can be reprogrammed at the bioelectric level independently of DNA, inverting the software/hardware metaphor
Planarian bioelectric circuits can enter a metastable cryptic state where they stochastically produce one- or two-headed worms upon each amputation, analogous to perceptual bistability.claim0.837
Links cognitive and morphogenetic dynamics.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.826
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.824
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.824
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.