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leiden_hybrid_concepts
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community:leiden_hybrid_concepts-run4-c12-c2Bioelectric control of planarian head patterning
Experimental manipulation of resting membrane potential patterns to stably alter morphogenesis (head number/location) independent of genetic sequence, primarily in Dugesia species 2011-2017.
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Findings (7)
- Bioelectric Head Patterning in PlanariaBioelectric gradients regionalize gene expression to determine head structure in planaria; system can be hijacked by microbes to control host head number and morphology.
- Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedManipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.
- Cryptic planaria exhibit stochastic but concordant head/tail decisionsBioelectrical disruption produces planaria forming 2-head or 1-head forms at ~70-30 ratio; randomization occurs at population level, but each worm makes unified decision across all tissues.
- Cryptic planaria fragments form 1-head and 2-head forms at a set frequency of ~1:2 (Durant et al. 2017)Shows stochastic anatomical outcome at the individual level while all cells in a fragment agree on one morphology.
- In planaria, the most depolarized region becomes the head; altering bioelectric pattern changes head location and number (Beane et al. 2011, Durant et al. 2017)The collective interprets relative voltage differences, not absolute values, to decide anterior identity.
- Manipulation of resting potential pattern in planaria stably alters target morphology (head number) despite wild-type genetics.Transient bioelectric perturbation with ion channel drugs/RNAi permanently alters the number of heads regenerated even in subsequent rounds without further treatment, demonstrating bioelectric pattern memory.
- Permanent two-headed planarians created by manipulating bioelectric circuits.From Oviedo et al. (2010) and Durant et al. (2017), shows memory of anatomical set points beyond genomic default.