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finding:manipulation-of-resting-potential-pattern-in-planaria-stably-alters-target-morphology-head-number-despite-wild-type-genetics

Manipulation of resting potential pattern in planaria stably alters target morphology (head number) despite wild-type genetics.

Transient bioelectric perturbation with ion channel drugs/RNAi permanently alters the number of heads regenerated even in subsequent rounds without further treatment, demonstrating bioelectric pattern memory.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Levin, Michael

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Claims (1)

claim

Bioelectric networks scale cell computation into anatomical homeostasis and are a mechanism for evolving larger Selves.
supports
Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.

Communities (3)

community

Bioelectric memory & morphogenetic identity
members_of
Gap junctions and bioelectric signals encode body-plan and memory patterns across radical biological transformation.
Bioelectric control of planarian morphogenesis
members_of
Transient bioelectric manipulation persistently alters head number and patterning despite wild-type genetics in planaria.
Bioelectric control of planarian head patterning
members_of
Experimental manipulation of resting membrane potential patterns to stably alter morphogenesis (head number/location) independent of genetic sequence, primarily in Dugesia species 2011-2017.

Concepts (1)

concept

Pattern Memory
supports
Stored representation of correct anatomical goal, stable yet rewritable by physiological experience; basis for morphospace navigation.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.872
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
Genetically wild-type planaria can be induced to adopt head shapes of other species by brief bioelectric modulation, crossing 100-150 My evolutionary distance in days.finding0.849
From Sullivan et al. 2016 and Emmons-Bell et al. 2015; demonstrates that large morphospace distances can be crossed by physiological manipulation.
Planaria permanently generate two-headed forms despite completely wild-type genetic sequence after bioelectric pattern rewriting.finding0.836
Demonstrates that anatomical outcomes can be reprogrammed at the bioelectric level independently of DNA, inverting the software/hardware metaphor
The same wild-type genome can produce 1-, 2-, or 0-headed planaria depending on bioelectric history, showing that anatomical outcome is not directly encoded in the genome.claim0.828
Demonstrates the role of epigenetic bioelectric software.
Planaria have fully committed to a strategy that overrides genetic details with large-scale pattern completion.claim0.827
Interpretive claim explaining planarian robustness as top-down morphogenetic intelligence.
Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.818
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Bioelectric signatures control morphogenetic target patterns; transient bioelectrical modulation in planaria produces persistent two-headed phenotype.finding0.816
Pattern memory in planaria can be re-written non-genetically via transient modification of membrane potential, leading to permanent changes in target morphology.claim0.812
Summarizes the two-headed planarian phenomenon.

Cross-corpus bridges (1)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

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How can systems with messy, polyploid genomes maintain the most robust morphological control?questions/how-can-systems-with-messy-polyploid-genomes-maintain.md0.801