finding

active

finding:transient-perturbation-of-bioelectric-states-produces-stable-two-headed-planaria-that-regenerate-true

Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate true

Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

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Claims (1)

claim

Developmental bioelectricity provides a tractable entrypoint into the informational architecture of the collective intelligence of morphogenesis.
supports
Bioelectric patterns serve as re-writable pattern memories for anatomical homeostasis.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.878
Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.
Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.finding0.874
Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.
Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.867
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.858
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).finding0.855
Shows reversibility of bioelectric pattern memory.
Planarian bioelectric circuits can enter a metastable cryptic state where they stochastically produce one- or two-headed worms upon each amputation, analogous to perceptual bistability.claim0.834
Links cognitive and morphogenetic dynamics.
Bioelectric signatures control morphogenetic target patterns; transient bioelectrical modulation in planaria produces persistent two-headed phenotype.finding0.833
Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedfinding0.830
Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.