finding

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finding:transient-bioelectrical-modulation-shifts-planarians-to-persistent-two-headed-regenerative-state-despite-unaltered-genomes-phenotype-persists-through-subsequent-amputations

Transient bioelectrical modulation shifts planarians to persistent two-headed regenerative state despite unaltered genomes; phenotype persists through subsequent amputations.

Empirical validation of hypothesis that morphogenetic targets encoded in bioelectric networks can be rewritten without genetic modification.

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Hypotheses (1)

hypothesis

If intercellular signaling (not genes) is the cognitive medium of morphogenesis, then bioelectric signals can be read, interpreted, and rewritten to predictively control growth and form without genetic changes.
supports
Predictive hypothesis validated in planarians and other species; enables therapeutic manipulation of morphogenetic targets.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Transient bioelectrical modulation of body-wide pattern memory circuits in planaria can shift them from one-headed to persistent two-headed state, persisting through amputation rounds until reset with different manipulation.finding0.906
Experimental evidence that organism-scale goals can be rewritten through physiological signals without genetic modification; demonstrates bioelectricity as cognitive medium.
Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.897
Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.874
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
Bioelectric signatures control morphogenetic target patterns; transient bioelectrical modulation in planaria produces persistent two-headed phenotype.finding0.862
Bioelectrical modulation can revert two-headed planaria back to normal (Durant et al. 2017).finding0.844
Shows reversibility of bioelectric pattern memory.
Planarian bioelectric circuits can enter a metastable cryptic state where they stochastically produce one- or two-headed worms upon each amputation, analogous to perceptual bistability.claim0.842
Links cognitive and morphogenetic dynamics.
Bioelectric perturbation permanently alters planarian head number to two-headed or zero-headedfinding0.823
Manipulation of Vmem via gap junction or ion channel drugs rewrites pattern memory, causing planaria to regenerate with stable, heritable aberrant head numbers.
Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.818
From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.