Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.

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Communities (3)

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Bioelectric morphogenesis & anatomical intelligence
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Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Gap junctions & collective morphogenetic selfhood
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Levin-framework linking gap junction bioelectricity to cancer, planaria, and scaling of cellular Selves.
Morphological cognition and collective cellular intelligence
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Cells as goal-directed agents maintaining anatomical representations through gap-junction-mediated information integration; cancer as cognitive defection when collective Self boundaries collapse.

Source docs (1)

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alexander-and-levin.md
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Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.822
Highlights the non-genetic control of large-scale anatomy.
How cells build specific head shapes or how they know when to stop mitosis and morphogenesis when the correct head shape has been achieved.question0.813
Identifies the gap in understanding the setpoints and stop signals in anatomical homeostasis.
Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.808
Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
How Do Cells Compute And Maintain Anatomical Targetquestion0.804
Cancer can be seen as a breakdown of the binding process that scales Selves, with cells reverting to unicellular goals.claim0.797
Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
Understanding Self-plasticity and morphogenesis has direct implications for regenerative medicine and neural repair.claim0.789
Bioelectric networks scale cell computation into anatomical homeostasis and are a mechanism for evolving larger Selves.claim0.787
Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.
The large-scale morphological goals of an organism override and harness the local competencies of individual cells to adaptively navigate morphospace.claim0.785
Describes top-down control in morphogenesis.

Cross-corpus bridges (12)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

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How does a collective of cells store and measure information about correct anatomical target morphologies?questions/how-does-a-collective-of-cells-store-and.md0.846
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How do cellular collectives achieve consensus on morphological targets during development and regeneration?questions/how-do-cellular-collectives-achieve-consensus-on-morphological.md0.839
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How do cells collectively solve morphogenetic problems without centralized control or neural computation?questions/how-do-cells-collectively-solve-morphogenetic-problems-without.md0.836
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How do cells compute and maintain anatomical target states during regeneration despite genetic degeneracy and noise?questions/how-do-cells-compute-and-maintain-anatomical-target.md0.835
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How do cells scale setpoint states from individual homeostasis to collective anatomical goals?questions/how-do-cells-scale-setpoint-states-from-individual.md0.831
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How do organisms solve the problem of specifying and maintaining complex anatomical structures?questions/how-do-organisms-solve-the-problem-of-specifying.md0.828
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How do cells collectively maintain alignment around shared goal states in anatomical morphospace without centralized direction?questions/how-do-cells-collectively-maintain-alignment-around-shared.md0.827
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What role do bioelectric patterns play in maintaining and enabling regeneration of anatomical target states?questions/what-role-do-bioelectric-patterns-play-in-maintaining.md0.827
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How do biological systems maintain anatomically correct form despite environmental perturbations and cellular rearrangement?questions/how-do-biological-systems-maintain-anatomically-correct-form.md0.822
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What factors enable polyploid organisms to maintain normal development despite vastly enlarged cells?questions/what-factors-enable-polyploid-organisms-to-maintain-normal.md0.819
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How do multicellular systems maintain coherent identity and solve problems collectively despite lacking central control?questions/how-do-multicellular-systems-maintain-coherent-identity-and.md0.818
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How is the bioelectric target morphology setpoint stored and maintained during development, regeneration, and throughout life?questions/how-is-the-bioelectric-target-morphology-setpoint-stored.md0.813