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question:how-cells-build-specific-head-shapes-or-how-they-know-when-to-stop-mitosis-and-morphogenesis-when-the-correct-head-shape-has-been-achieved

How cells build specific head shapes or how they know when to stop mitosis and morphogenesis when the correct head shape has been achieved.

Identifies the gap in understanding the setpoints and stop signals in anatomical homeostasis.

Source paper

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Collective intelligence: A unifying concept for integrating biology across scales and substrates

(2024) · Patrick McMillen · Michael Levin

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Claims (1)

claim

Regulative morphogenesis is a kind of behavior of cellular collectives traversing anatomical morphospace.
gates
Posits that the collective movement toward a target morphology is akin to goal-directed behavior.

Concepts (1)

concept

Anatomical Homeostasis
gates
Ability of organisms to adjust anatomy despite injury or rearrangement; demonstrates collective problem-solving in morphospace.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.claim0.813
When a subset of cells is given a morphogenetic goal (e.g., build an eye), they autonomously recruit unmodified neighbors to complete the structure, showing modular competency.claim0.809
Principle of top-down control.
Morphogenesis is a result of collective activity where cells cooperate toward a specific, invariant target morphology, exhibiting goal-directedness.claim0.798
Frames developmental biology as an instance of basal cognition.
Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.789
Highlights the non-genetic control of large-scale anatomy.
What shape head would regenerate (and would it ever reach the stop criterion and cease remodeling)?question0.786
Thought experiment from Figure 5c asking what happens when half the neoblasts are from a different species.
Morphogenesis can be viewed as the result of the behavior of swarm intelligence of cells.claim0.779
Cells collectively solve anatomical problems, analogous to collective intelligence in social insects.
Producing the exact shape from personal vision brings the thing to lifeclaim0.778
The styrofoam method allows the exact shape felt right to be produced, and that personal exactness yields spiritual quality.
Morphogenesis operates through multiscale autopoietic processes in which every cell is simultaneously an environment for others, enabling coherent organism formation without predetermined configuration.finding0.778

Cross-corpus bridges (4)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

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How do cells collectively determine body form without centralized control?questions/how-do-cells-collectively-determine-body-form-without.md0.833
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How does a collective of cells store and measure information about correct anatomical target morphologies?questions/how-does-a-collective-of-cells-store-and.md0.832
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What determines the collective decision-making processes by which chimeric cells of different species establish shared morphology?questions/what-determines-the-collective-decisionmaking-processes-by-which.md0.804
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How do cells know what the correct anatomical configuration should be and measure whether they have reached it?questions/how-do-cells-know-what-the-correct-anatomical.md0.800