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question:what-shape-head-would-regenerate-and-would-it-ever-reach-the-stop-criterion-and-cease-remodeling

What shape head would regenerate (and would it ever reach the stop criterion and cease remodeling)?

Thought experiment from Figure 5c asking what happens when half the neoblasts are from a different species.

Source paper

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Collective intelligence: A unifying concept for integrating biology across scales and substrates

(2024) · Patrick McMillen · Michael Levin

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Findings (1)

finding

Modification of cell-cell communication during planarian regeneration causes genetically-normal fragments to produce heads appropriate to other species (Emmons-Bell et al. 2015, Sullivan et al. 2016)
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Shows that morphological attractors can be switched via physiological cues, revealing the navigation of morphospace by collectives.

Related by similarity (8)

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Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

How cells build specific head shapes or how they know when to stop mitosis and morphogenesis when the correct head shape has been achieved.question0.786
Identifies the gap in understanding the setpoints and stop signals in anatomical homeostasis.
Memories persist through complete brain remodeling during metamorphosis by transferring and remapping onto newly-constructed neural tissue.hypothesis0.747
Proposed mechanism explaining behavioral continuity in insects undergoing radical morphogenesis.
Amphibian limb regeneration ceases after repeated amputation (Bryant et al. 2017).finding0.737
Indicates that prior experience can alter morphogenetic capacity.
When environments are built by morphogenesis they will of their own accord become sustainable.claim0.732
First key empirical proposition of the lecture: morphogenetic processes inherently produce sustainable outcomes without explicit technical mandates.
Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.731
Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.
Transient perturbation of bioelectric states produces stable two-headed planaria that regenerate truefinding0.728
Manipulating gap junctions or ion channels can permanently alter the target morphology in planaria, resulting in two-headed animals that regenerate two heads without further intervention.
Understanding Self-plasticity and morphogenesis has direct implications for regenerative medicine and neural repair.claim0.727
Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.claim0.727