Amphibian limb regeneration ceases after repeated amputation (Bryant et al. 2017).

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• Artificially induced frog leg regeneration follows a non-developmental path (like a plant) to produce a normal limb.finding0.804
  Frog legs regenerated after specific induction did not form a paddle with interdigital apoptosis but grew digits from a central core, reaching correct final form via atypical intermediate states.
• Salamander limb regeneration exhibits precise morphological target-seekingfinding0.791
  Salamander limbs regenerate missing parts precisely and stop when target morphology is reached, demonstrating goal-directed morphogenesis.
• Salamander limb regenerationconcept0.775
  Biological example of anatomical homeostasis: amputated limb regrows and knows when to stop, demonstrating error-minimization and setpoint-seeking behavior.
• Salamanders regenerate limbs, jaws, eyes, tails, and ovaries.finding0.772
  From McCusker & Gardiner (2011), example of robust regenerative capacity.
• Tails transplanted to salamander flank gradually remodel into limb-like structures.finding0.751
  Farinella-Ferruzza 1956 finding on global pattern overriding local identity.
• What shape head would regenerate (and would it ever reach the stop criterion and cease remodeling)?question0.737
  Thought experiment from Figure 5c asking what happens when half the neoblasts are from a different species.
• Wounds on deer antlers are remembered and reproduced in subsequent years at the same location.finding0.731
  Deer farmers observed that a wound on a branched antler results in ectopic tine at that location next year, long after the original antler fell off, indicating spatial pattern memory.
• Planarian fragments regenerating from bioelectrically re-patterned tissue produce permanent two-headed phenotype, demonstrating transient bioelectric states can produce lasting morphological memory changes.finding0.725
  Key evidence that morphogenetic memories are stored in bioelectric circuits and are rewritable via transient voltage state modifications; memory persists across multiple regeneration cycles.