Salamander limb regeneration exhibits precise morphological target-seeking

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• Salamanders regenerate complete, correctly-scaled limbs regardless of the amputation levelfinding0.866
  Evidence for anatomical target-morphology goal states independent of injury specifics.
• Salamander limb regenerationconcept0.861
  Biological example of anatomical homeostasis: amputated limb regrows and knows when to stop, demonstrating error-minimization and setpoint-seeking behavior.
• Salamanders regenerate limbs, jaws, eyes, tails, and ovaries.finding0.848
  From McCusker & Gardiner (2011), example of robust regenerative capacity.
• Tails transplanted to salamander flank gradually remodel into limb-like structures.finding0.813
  Farinella-Ferruzza 1956 finding on global pattern overriding local identity.
• Amphibian limb regeneration ceases after repeated amputation (Bryant et al. 2017).finding0.791
  Indicates that prior experience can alter morphogenetic capacity.
• Artificially induced frog leg regeneration follows a non-developmental path (like a plant) to produce a normal limb.finding0.755
  Frog legs regenerated after specific induction did not form a paddle with interdigital apoptosis but grew digits from a central core, reaching correct final form via atypical intermediate states.
• Brief bioelectric manipulation can stably convert wild-type planaria to a two-headed target morphology that persists through regeneration.finding0.732
  From Durant et al. 2017; shows bioelectric pattern memory is reprogrammable without genomic change.
• Target morphologyconcept0.728
  The ideal anatomical pattern (e.g., smiling face) that cells aim to achieve.