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leiden_hybrid_concepts
label: sonnet
community:leiden_hybrid_concepts-run2-c18Gap junctions & collective morphogenetic selfhood
Levin-framework linking gap junction bioelectricity to cancer, planaria, and scaling of cellular Selves.
14 members. Each node is clickable.
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Drawn from 7 sources
The papers/notes whose extracted claims & findings make up this cluster.
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds10 members
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds3 members
- Biology, Buddhism, and AI: Care as the Driver of Intelligence1 member
- Toward an ethics of autopoietic technology: Stress, care, and intelligence1 member
- The computational boundary of a 'self': developmental bioelectricity drives multicellularity and scale-free cognition1 member
- alexander-and-levin.md1 member
- Collective intelligence: A unifying concept for integrating biology across scales and substrates1 member
Bridges (5)
Other communities that share members with this one — cross-cutting threads or papers that sit at the seam between two themes.
Claims (9)
- Cancer as loss of organizational self-boundaryLevin proposes cancer cells become isolated from physiological signals that bind them into organ-level collectives, reverting to unicellular-scale goals, shrinking their computational self.
- Cancer can be seen as a breakdown of the binding process that scales Selves, with cells reverting to unicellular goals.Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
- Cancer can be understood as a dissociative identity disorder of the morphological collective intelligence.Provocative reinterpretation of cancer as a failure mode of collective decision-making.
- Cancer is a breakdown of the collective intelligence of tissues, a shrinking of the Self boundary due to gap junction closure.Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.
- Gap junctional coupling partially erases informational boundaries between cells, enabling the scaling of the Self to tissue- and organ-level goals.Proposes a mechanism for how merging physiological states via gap junctions creates a new, larger cognitive agent.
- Gap junctional coupling wipes ownership information on signaling molecules, enabling the formation of multicellular Selves.Because cells cannot distinguish internally generated signals from those arriving through GJs, they share memories and bind into a larger agent.
- General anesthesia works by blocking gap junctions, thereby dissolving the higher-level Self while leaving individual cells functional.Suggests that the unified self emerges from bioelectrical network coherence, which can be reversibly disrupted.
- General anesthetics are gap junction blockers, consistent with the role of gap junctions in scaling consciousness.Links anesthesia mechanism to the bioelectric binding model of higher-level Selves.
- Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.
Findings (5)
- Carcinogenesis illustrates failure of SCI loop integration when cells revert to unicellular selves and detach from collective morphogenetic goals.
- Gap junction blockade stochastically induces heads of other planarian species in genetically wild-type worms.Temporary disruption of gap junctions causes planaria to reconstruct heads appropriate to other species, revealing latent morphospace attractors.
- Gap junctions enable 'mind meld' through impossibility of information hiding
- General anesthetics are gap junction blockers.Gap junction blockers function as anesthetics across plants, Hydra, and humans, consistent with GJs being critical for high-level Self maintenance.
- General anesthetics block gap junctions across plants, Hydra, and humansGap junction blockers induce loss of consciousness in diverse organisms, supporting the bioelectric network hypothesis of the Self.