finding
active
finding:general-anesthetics-are-gap-junction-blockersGeneral anesthetics are gap junction blockers.
Gap junction blockers function as anesthetics across plants, Hydra, and humans, consistent with GJs being critical for high-level Self maintenance.
Source paper
extracted_from(2022) · Levin, Michael
Neighborhood — ranked by edge-count
Claims (1)
claim
- Links anesthesia mechanism to the bioelectric binding model of higher-level Selves.
Communities (3)
community
- Gap junctions and bioelectric signals encode body-plan and memory patterns across radical biological transformation.
- Levin-framework linking gap junction bioelectricity to cancer, planaria, and scaling of cellular Selves.
- Explores how gap junction coupling enables multicellular self-organization and consciousness across species, with anesthetics as empirical probes of this bioelectric integration.
Concepts (1)
concept
- Gap JunctionssupportsCellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- The observation that gap junction blockers anesthetize diverse organisms, supporting the hypothesis that bioelectric networks implement the unified Self.
- Gap junction blockers induce loss of consciousness in diverse organisms, supporting the bioelectric network hypothesis of the Self.
- General anesthesia works by blocking gap junctions, thereby disrupting the higher-level cognitive self.hypothesis0.863Explains why anesthetics abolish consciousness in diverse organisms, including plants.
- Suggests that the unified self emerges from bioelectrical network coherence, which can be reversibly disrupted.
- Already supported by data in plants, Hydra, and humans, but broader cross-species testing is predicted.
- Model system for mind rebooting after bioelectric network disruption.
- Pharmacological blockade of gap junctional communication used to alter morphological pattern memory and scaling.
- Temporary disruption of gap junctions causes planaria to reconstruct heads appropriate to other species, revealing latent morphospace attractors.
Restated by (1)
cosine ≥ 0.90Other entities that say roughly the same thing. May be merge candidates or independent restatements across papers.