method
active
method:gap-junction-blockadeGap junction blockade
Pharmacological blockade of gap junctional communication used to alter morphological pattern memory and scaling.
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Concepts (1)
concept
- Gap Junctionssubtype_ofCellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.
Artifacts (1)
artifact
- The source paper introducing the TAME framework, published in Frontiers in Systems Neuroscience.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- The observation that gap junction blockers anesthetize diverse organisms, supporting the hypothesis that bioelectric networks implement the unified Self.
- Using drugs or genetic tools to open/close gap junctions and probe bioelectric networks in development.
- Gap junction blockers function as anesthetics across plants, Hydra, and humans, consistent with GJs being critical for high-level Self maintenance.
- Gap junction blockers induce loss of consciousness in diverse organisms, supporting the bioelectric network hypothesis of the Self.
- The process by which cells lose individuality and form a collective cognitive unit through gap junctional coupling.
- Temporary disruption of gap junctions causes planaria to reconstruct heads appropriate to other species, revealing latent morphospace attractors.
- Already supported by data in plants, Hydra, and humans, but broader cross-species testing is predicted.