Gap junction blockade as general anesthesia

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• General anesthetics are gap junction blockers.finding0.913
  Gap junction blockers function as anesthetics across plants, Hydra, and humans, consistent with GJs being critical for high-level Self maintenance.
• General anesthetics are gap junction blockers, consistent with the role of gap junctions in scaling consciousness.claim0.873
  Links anesthesia mechanism to the bioelectric binding model of higher-level Selves.
• General anesthetics block gap junctions across plants, Hydra, and humansfinding0.871
  Gap junction blockers induce loss of consciousness in diverse organisms, supporting the bioelectric network hypothesis of the Self.
• General anesthesia works by blocking gap junctions, thereby disrupting the higher-level cognitive self.hypothesis0.855
  Explains why anesthetics abolish consciousness in diverse organisms, including plants.
• General anesthesia works by blocking gap junctions, thereby dissolving the higher-level Self while leaving individual cells functional.claim0.843
  Suggests that the unified self emerges from bioelectrical network coherence, which can be reversibly disrupted.
• Gap junction blockademethod0.837
  Pharmacological blockade of gap junctional communication used to alter morphological pattern memory and scaling.
• If gap junction-mediated bioelectric networks implement the unified Self, then gap junction blockers should function as general anesthetics across biology.hypothesis0.823
  Already supported by data in plants, Hydra, and humans, but broader cross-species testing is predicted.
• general anesthesiaconcept0.773
  Model system for mind rebooting after bioelectric network disruption.