If gap junction-mediated bioelectric networks implement the unified Self, then gap junction blockers should function as general anesthetics across biology.

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• General anesthetics are gap junction blockers, consistent with the role of gap junctions in scaling consciousness.claim0.852
  Links anesthesia mechanism to the bioelectric binding model of higher-level Selves.
• General anesthetics block gap junctions across plants, Hydra, and humansfinding0.850
  Gap junction blockers induce loss of consciousness in diverse organisms, supporting the bioelectric network hypothesis of the Self.
• General anesthesia works by blocking gap junctions, thereby dissolving the higher-level Self while leaving individual cells functional.claim0.832
  Suggests that the unified self emerges from bioelectrical network coherence, which can be reversibly disrupted.
• Bioelectric networks formed by gap junctions scale cell-level homeostatic loops into organ-level anatomical homeostasis.hypothesis0.825
  Proposed mechanism for scaling of goal-directed activity from cells to tissues.
• Gap junction blockade as general anesthesiaconcept0.823
  The observation that gap junction blockers anesthetize diverse organisms, supporting the hypothesis that bioelectric networks implement the unified Self.
• General anesthetics are gap junction blockers.finding0.822
  Gap junction blockers function as anesthetics across plants, Hydra, and humans, consistent with GJs being critical for high-level Self maintenance.
• General anesthesia works by blocking gap junctions, thereby disrupting the higher-level cognitive self.hypothesis0.816
  Explains why anesthetics abolish consciousness in diverse organisms, including plants.
• Gap junctional coupling partially erases informational boundaries between cells, enabling the scaling of the Self to tissue- and organ-level goals.claim0.804
  Proposes a mechanism for how merging physiological states via gap junctions creates a new, larger cognitive agent.