hypothesis

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hypothesis:cells-exhibit-generalization-in-physiological-space-recognizing-novel-stressors-as-members-of-familiar-classes-to-deploy-transcriptional-solutions

Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.

Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.

Source paper

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Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

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Papers (1)

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Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds
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Related by similarity (8)

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Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

We hypothesize that cell collectives use voltage as a generalization parameter to repurpose responses for novel stress conditions.hypothesis0.840
Barium planaria experiment suggests cells generalize via physiological stress classes, with Vmem as macrovariable.
Cells and cellular networks have problem-solving capacities that allow them to navigate entirely novel stressors (e.g., barium) without prior selection, implying a general competency beyond hardwired responses.claim0.831
Derived from the planarian barium adaptation finding.
Cells navigate multiple problem spaces: physiological, metabolic, transcriptional, anatomicalclaim0.822
Stressed cells leak stress signals to neighbors, raising their plasticity and enabling them to create temporary passages (tunnels) for movement.hypothesis0.822
By sharing stress with neighbors, one cell’s (or region’s) problem becomes everyone’s problem, leading to a higher willingness to adopt new configurations in which everyone’s free energy is lower (and thus, more optimal morphogenetic problem-solving).quote0.818
Encapsulates the core idea of stress sharing as collective cooperation.
Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.hypothesis0.811
Prior hypothesis tested in the paper; from Levin 2022.
Cells maintain internal representations of correct anatomical structure (target morphology) that causally constrain growth, regeneration, and repair.claim0.808
Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.807
Highlights the non-genetic control of large-scale anatomy.

Cross-corpus bridges (12)

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How do cells share stress information to enable larger-scale collective morphogenetic goals?questions/how-do-cells-share-stress-information-to-enable.md0.839
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How do cells scale setpoint states from individual homeostasis to collective anatomical goals?questions/how-do-cells-scale-setpoint-states-from-individual.md0.839
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What mechanisms enable groups of cells to cooperate toward specific anatomical outcomes?questions/what-mechanisms-enable-groups-of-cells-to-cooperate.md0.836
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How do individual cells with their own homeostatic competencies coordinate to achieve larger-scale, reliable morphological endpoints?questions/how-do-individual-cells-with-their-own-homeostatic.md0.835
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What mechanisms allow the homeostatic capabilities of individual cells to relate to the more complex homeostatic setpoints of the collective?questions/what-mechanisms-allow-the-homeostatic-capabilities-of-individual.md0.833
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Could persistent physiological patterns (stress states, regulatory setpoints) function as thoughts-as-agents that partially constitute the identity of an organism?questions/could-persistent-physiological-patterns-stress-states-regulatory-setpoints.md0.828
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How do cells maintain competency for novel behaviors that are normally suppressed by developmental context?questions/how-do-cells-maintain-competency-for-novel-behaviors.md0.820
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What is it like to be a cell or tissue under stress, and how does stress constitute felt prediction error?questions/what-is-it-like-to-be-a-cell.md0.819
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Can human cells retain specialized functions while reorganizing into novel multicellular forms?questions/can-human-cells-retain-specialized-functions-while-reorganizing.md0.818
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Stress-Induced Evolutionary Innovationframeworks/stress-induced-evolutionary-innovation.md0.817
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What computations, algorithms or dynamics enable cellular collectives to respond adaptively, reaching the same form and function despite radical induced changes of circumstances?questions/what-computations-algorithms-or-dynamics-enable-cellular-collectives.md0.813
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How do homeostatic capabilities of individual cells relate to complex homeostatic setpoints of collectives?questions/how-do-homeostatic-capabilities-of-individual-cells-relate.md0.811