Stressed cells leak stress signals to neighbors, raising their plasticity and enabling them to create temporary passages (tunnels) for movement.

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• Stress molecules leak from source cells and diffuse to neighbors, making shared stress a conserved signal for cooperation.claim0.836
  Central hypothesis that stress sharing enables cooperation without explicit altruism by making individual problems collective.
• Cells should leak molecules such as HSP90 extracellularly as a stress sharing mechanism.claim0.833
  Prediction for in-vivo biology from the model.
• Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.822
  Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
• By sharing stress with neighbors, one cell’s (or region’s) problem becomes everyone’s problem, leading to a higher willingness to adopt new configurations in which everyone’s free energy is lower (and thus, more optimal morphogenetic problem-solving).quote0.814
  Encapsulates the core idea of stress sharing as collective cooperation.
• Stress sharing reduces the functional inertia of low-stress cells, increasing their plasticity and exploratory behavior.claim0.813
  Shared stress raises the 'temperature' or exploratory activity of neighboring cells, enabling passage for stressed cells.
• How Does Stress Sharing Enable Cells To Navigatequestion0.812
• "By sharing stress with neighbors, one cell's problem becomes everyone's problem, leading to a higher willingness to adopt new configurations."concept0.811
  Load-bearing statement capturing the core mechanism of stress sharing as social coordination.
• By sharing stress with neighbors, one cell's (or region's) problem becomes everyone's problem, leading to a higher willingness to adopt new configurations in which everyone's free energy is lower.concept0.807