Cells should leak molecules such as HSP90 extracellularly as a stress sharing mechanism.

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• Stress molecules leak from source cells and diffuse to neighbors, making shared stress a conserved signal for cooperation.claim0.862
  Central hypothesis that stress sharing enables cooperation without explicit altruism by making individual problems collective.
• Stressed cells leak stress signals to neighbors, raising their plasticity and enabling them to create temporary passages (tunnels) for movement.hypothesis0.833
• By sharing stress with neighbors, one cell’s (or region’s) problem becomes everyone’s problem, leading to a higher willingness to adopt new configurations in which everyone’s free energy is lower (and thus, more optimal morphogenetic problem-solving).quote0.812
  Encapsulates the core idea of stress sharing as collective cooperation.
• Stress sharing reduces the functional inertia of low-stress cells, increasing their plasticity and exploratory behavior.claim0.806
  Shared stress raises the 'temperature' or exploratory activity of neighboring cells, enabling passage for stressed cells.
• Stress sharing is an easy way to achieve robustness in collectives made up of homeostatic subunits.claim0.800
  Generalization of the model's implications.
• Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.hypothesis0.796
  Prior hypothesis tested in the paper; from Levin 2022.
• By sharing stress with neighbors, one cell's (or region's) problem becomes everyone's problem, leading to a higher willingness to adopt new configurations in which everyone's free energy is lower.concept0.795
• How Do Cells Share Stress Information To Enablequestion0.795