Sharing of stress between cells facilitates morphogenesis and increases robustness of morphogenetic outcomes.

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• We hypothesize that stress sharing improves morphogenetic efficiency and increases cohesiveness of multicellular collectives.hypothesis0.898
  Central predictive hypothesis motivating the quantitative agent-based modeling.
• By sharing stress with neighbors, one cell’s (or region’s) problem becomes everyone’s problem, leading to a higher willingness to adopt new configurations in which everyone’s free energy is lower (and thus, more optimal morphogenetic problem-solving).quote0.869
  Encapsulates the core idea of stress sharing as collective cooperation.
• Stress sharing reduces the functional inertia of low-stress cells, increasing their plasticity and exploratory behavior.claim0.850
  Shared stress raises the 'temperature' or exploratory activity of neighboring cells, enabling passage for stressed cells.
• Sequential morphogenesis causes stress to fluctuate over the course of development.claim0.839
  Observation from part-by-part target experiment.
• Stress sharing works to increase cohesiveness of collectives by raising exploratory plasticity in neighboring cells, enabling long-distance cell influencehypothesis0.839
• In stress-sharing embryo, average stress reduced to zero at step 40 during sequential target morphogenesis; without-sharing stress settled at non-zero with <55 cells movingfinding0.838
  Shows stress sharing allows perfect formation of part-by-part target patterns.
• Stress sharing will be favored by evolutionary processes.hypothesis0.828
  Evolutionary fitness hypothesis tested in the GA.
• Stress-sharing embryos achieve perfect sequential target patterns; non-sharing limited to <1% improvement.finding0.827
  Stress-sharing embryos formed each sequential target with stress reducing to zero; non-sharing achieved only tiny improvements.