Cells navigate multiple problem spaces: physiological, metabolic, transcriptional, anatomical

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• Diverse Problem Spaces (3D, morphospace, transcriptional, physiological)concept0.830
  Intelligence is defined by navigating not just 3D space but also anatomical, gene expression, and physiological spaces.
• Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.822
  Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
• The deep symmetry between problem-solving in anatomical, physiological, transcriptional, and 3D spaces drives specific hypotheses.claim0.794
  Evolution pivoted the same problem-solving strategies across different domains.
• Cellular collectives navigate morphological problem space via error minimizationclaim0.793
• Cells and cellular networks have problem-solving capacities that allow them to navigate entirely novel stressors (e.g., barium) without prior selection, implying a general competency beyond hardwired responses.claim0.788
  Derived from the planarian barium adaptation finding.
• Problem Spaces in Biologyconcept0.785
  Diverse spaces in which biological systems solve problems: physiological, metabolic, transcriptional, and anatomical; cells navigate these via adaptive behavior and information processing.
• The large-scale morphological goals of an organism override and harness the local competencies of individual cells to adaptively navigate morphospace.claim0.776
  Describes top-down control in morphogenesis.
• Cancer is a breakdown of the multiscale binding, leading cells to revert to unicellular goals.hypothesis0.773
  Gap junction closure makes cells selfish, shrink their cognitive boundary; restoring Vmem can normalize.