Cells and cellular networks have problem-solving capacities that allow them to navigate entirely novel stressors (e.g., barium) without prior selection, implying a general competency beyond hardwired responses.

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• Cells exhibit generalization in physiological space, recognizing novel stressors as members of familiar classes to deploy transcriptional solutions.hypothesis0.831
  Predicts that cells can categorize perturbations and mount appropriate, not just hardwired, responses.
• By sharing stress with neighbors, one cell's (or region's) problem becomes everyone's problem, leading to a higher willingness to adopt new configurations in which everyone's free energy is lower.concept0.821
• By sharing stress with neighbors, one cell’s (or region’s) problem becomes everyone’s problem, leading to a higher willingness to adopt new configurations in which everyone’s free energy is lower (and thus, more optimal morphogenetic problem-solving).quote0.821
  Encapsulates the core idea of stress sharing as collective cooperation.
• "By sharing stress with neighbors, one cell's problem becomes everyone's problem, leading to a higher willingness to adopt new configurations."concept0.821
  Load-bearing statement capturing the core mechanism of stress sharing as social coordination.
• Learning neural networks can enable 'chunking' and rescale problem-solving to higher organizational levels, a mechanism intrinsic to transitions in individuality.hypothesis0.807
• Stressed cells leak stress signals to neighbors, raising their plasticity and enabling them to create temporary passages (tunnels) for movement.hypothesis0.802
• We hypothesize that cell collectives use voltage as a generalization parameter to repurpose responses for novel stress conditions.hypothesis0.800
  Barium planaria experiment suggests cells generalize via physiological stress classes, with Vmem as macrovariable.
• Bioelectric networks, with their inherent plasticity, multiscale historicity, and learning capacity, are an ideal kind of 'cognitive glue' that binds the primitive goal-directedness of single cells into a higher order system.concept0.798
  Canonical definition of the paper's central concept; encapsulates mechanism of cognitive scaling through bioelectric integration.