hypothesis
active
hypothesis:cancer-is-a-breakdown-of-the-multiscale-binding-leading-cells-to-revert-to-unicellular-goalsCancer is a breakdown of the multiscale binding, leading cells to revert to unicellular goals.
Gap junction closure makes cells selfish, shrink their cognitive boundary; restoring Vmem can normalize.
Source paper
extracted_from(2022) · Michael Levin
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Concepts (1)
concept
- Gap JunctionsaboutCellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
- Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.
- The view that cancer is a shrinking of the Self boundary due to gap junction closure, reverting cells to unicellular goals.
- Uses the cognitive light cone concept to offer a new framing of cancer as a collective intelligence defection
- The model that cancer results from cells shrinking their computational boundaries (closing gap junctions) and reverting to unicellular goals.
- Empirical support for the cancer-as-cognitive-defect / cognitive light cone shrinkage hypothesis
- Implicit predictive hypothesis from the cancer-as-cognitive-defect claim, with experimental implications for regenerative medicine
Cross-corpus bridges (6)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbIs cancer fundamentally a problem of loss of collective coordination and shared goals at the cellular level?questions/is-cancer-fundamentally-a-problem-of-loss-of.md0.845
- aboutblank_kbCancerconcepts/biology/cancer.md0.834
- aboutblank_kbCan cancer be understood and treated as a scaling problem of cellular identity?questions/can-cancer-be-understood-and-treated-as-a.md0.828
- aboutblank_kbHow do individual cell-level goals scale up into coherent organism-level Selves without central control?questions/how-do-individual-celllevel-goals-scale-up-into.md0.823
- aboutblank_kbHow do organism-level goals emerge from and constrain cellular-level interactions?questions/how-do-organismlevel-goals-emerge-from-and-constrain.md0.808
- aboutblank_kbMulticellularity-Cancer Dynamicconcepts/biology/multicellularity-cancer-dynamic.md0.790