Disruptions in cells' ability to join into a cohesive information-processing network via oncogenes and other factors correlate with cancer development

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• Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.823
  Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
• Cancer can be seen as a breakdown of the binding process that scales Selves, with cells reverting to unicellular goals.claim0.816
  Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
• Cancer is a breakdown of the collective intelligence of tissues, a shrinking of the Self boundary due to gap junction closure.claim0.816
  Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.
• Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.813
  Shows that restoring bioelectric cohesion can override single-cell goals.
• If cancer represents a shrinkage of the cognitive light cone, then interventions that restore cellular participation in tissue-level information-processing networks should suppress cancer progression.hypothesis0.806
  Implicit predictive hypothesis from the cancer-as-cognitive-defect claim, with experimental implications for regenerative medicine
• Cancerous growth can be induced by disruption of electrical coordination signals and reversed by re-establishing them, without genetic changes (Levin 2021a)finding0.805
  Empirical finding in developmental biology that supports organismic individuality independent of genetics
• Cancer can be normalized by reconnecting cells to the electrical network that harnesses them toward adaptive tissue homeostasis.claim0.804
  Proposes a non-toxic cancer treatment strategy.
• Cancer is a breakdown of the multiscale binding, leading cells to revert to unicellular goals.hypothesis0.802
  Gap junction closure makes cells selfish, shrink their cognitive boundary; restoring Vmem can normalize.