Cancer as breakdown of multicellularity

The view that cancer is a shrinking of the Self boundary due to gap junction closure, reverting cells to unicellular goals.

Neighborhood — ranked by edge-count

concept

Gap Junctions
associated_with
Cellular connections that enable bioelectric communication; form bioelectric networks underlying morphogenetic control and can be manipulated experimentally via molecular reagents.

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Cancer is a breakdown of the multiscale binding, leading cells to revert to unicellular goals.hypothesis0.843
Gap junction closure makes cells selfish, shrink their cognitive boundary; restoring Vmem can normalize.
Multicellularity Cancer Dynamicconcept0.841
Cancer as Defection from Multicellular Selfconcept0.832
The model that cancer results from cells shrinking their computational boundaries (closing gap junctions) and reverting to unicellular goals.
Cancer is a breakdown of the collective intelligence of tissues, a shrinking of the Self boundary due to gap junction closure.claim0.805
Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.
Cancer can be seen as a breakdown of the binding process that scales Selves, with cells reverting to unicellular goals.claim0.801
Oncogene-induced gap junction closure shrinks the cognitive boundary of cells.
Disruptions in cells' ability to join into a cohesive information-processing network via oncogenes and other factors correlate with cancer developmentfinding0.775
Empirical support for the cancer-as-cognitive-defect / cognitive light cone shrinkage hypothesis
Cancerconcept0.761
cancer of structure destructionconcept0.761
Metaphor: when the structure-preserving rule is violated, chaos and harm spread like cancer.