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finding:newt-kidney-tubule-lumen-diameter-is-maintained-with-fewer-larger-cells-by-switching-to-a-single-cell-wrapping-mechanism

Newt kidney tubule lumen diameter is maintained with fewer, larger cells by switching to a single-cell wrapping mechanism

When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.

Source paper

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Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

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Claims (1)

claim

Multi-scale competency architecture smoothens the fitness landscape, reduces pleiotropy, enables exploitation of opportunities, and improves controllability, thereby potentiating evolution.
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MCA provides evolvability advantages by buffering negative mutation effects and enabling independent selection of traits.

Communities (2)

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Tubule size invariance via cell number compensation
members_of
Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
Polyploid cell size compensation in tubulogenesis
members_of
Newt kidney tubules maintain correct lumen diameter despite ploidy-induced cell enlargement via number and wrapping adjustments.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Newt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).finding0.889
Shows multi-scale anatomical homeostasis using different cellular mechanisms.
Single newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.finding0.889
From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
Polyploid newts maintain normal kidney tubule size via cell number adjustment or single-cell wrapping, using different molecular mechanisms.finding0.883
From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.
Newt kidney tubule cells, when artificially enlarged, can bend a single cell around itself to achieve correct tubule diameter, illustrating top-down control over molecular mechanisms.claim0.880
Extreme example of regulative flexibility.
Polyploid newts maintain normal kidney tubule diameters using fewer, larger cells.finding0.873
Fankhauser 1945 finding on anatomical regulation despite ploidy changes.
Enlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.finding0.865
When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
Enlarged polyploid cells produce normal-sized kidney tubules by adjusting cell number and using cytoskeletal bendingfinding0.795
Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
Single enlarged cells can form proper tubules through cytoskeletal bending alonefinding0.788