claim
active
claim:newt-kidney-tubule-cells-when-artificially-enlarged-can-bend-a-single-cell-around-itself-to-achieve-correct-tubule-diameter-illustrating-top-down-control-over-molecular-mechanismsNewt kidney tubule cells, when artificially enlarged, can bend a single cell around itself to achieve correct tubule diameter, illustrating top-down control over molecular mechanisms.
Extreme example of regulative flexibility.
Source paper
extracted_from(2023) · Levin, Michael
Neighborhood — ranked by edge-count
Papers (1)
paper
Findings (2)
finding
- When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Shows multi-scale anatomical homeostasis using different cellular mechanisms.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Single newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.finding0.922From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
- When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.
- Extreme case showing the system switches molecular mechanism (cytoskeletal bending vs cell-cell communication) to hit the same anatomical target.
- Fankhauser 1945 finding on anatomical regulation despite ploidy changes.
- Polyploid newt kidney tubules use fewer, larger cells to maintain identical organ-level structurefinding0.842Illustrates that anatomical goals are pursued via flexible molecular mechanisms rather than fixed cell-count programs.
- Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
Restated by (2)
cosine ≥ 0.90Other entities that say roughly the same thing. May be merge candidates or independent restatements across papers.
- findingEnlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.
- findingNewt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).