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finding:polyploid-newts-maintain-normal-kidney-tubule-size-via-cell-number-adjustment-or-single-cell-wrapping-using-different-molecular-mechanisms

Polyploid newts maintain normal kidney tubule size via cell number adjustment or single-cell wrapping, using different molecular mechanisms.

From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.

Source paper

extracted_from

Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology

(2023) · Levin, Michael

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Claims (1)

claim

MCA creates a more tractable search space by smoothing the fitness landscape, mitigating the inverse problem and enabling survival of mutations that would otherwise be deleterious.
supports
Subclaim.

Findings (1)

finding

Polyploid newts maintain normal kidney tubule diameters using fewer, larger cells.
restates
Fankhauser 1945 finding on anatomical regulation despite ploidy changes.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Newt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).finding0.888
Shows multi-scale anatomical homeostasis using different cellular mechanisms.
Single newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.finding0.885
From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
Newt kidney tubule lumen diameter is maintained with fewer, larger cells by switching to a single-cell wrapping mechanismfinding0.883
When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
Enlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.finding0.881
When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
Enlarged polyploid cells produce normal-sized kidney tubules by adjusting cell number and using cytoskeletal bendingfinding0.877
Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
Newt kidney tubule cells, when artificially enlarged, can bend a single cell around itself to achieve correct tubule diameter, illustrating top-down control over molecular mechanisms.claim0.877
Extreme example of regulative flexibility.
Polyploid Newt Kidney Tubule Adaptationfinding0.854
Engineered polyploid newts with abnormally large cells and extra chromosomes develop normal kidney tubule diameters by switching molecular mechanisms on-the-fly.
Polyploid Newt Kidney Size Compensationfinding0.848

Restated by (1)

cosine ≥ 0.90

Other entities that say roughly the same thing. May be merge candidates or independent restatements across papers.

finding
Polyploid newts maintain normal kidney tubule diameters using fewer, larger cells.