finding
active
finding:enlarged-newt-cells-compensate-for-increased-size-by-adjusting-cell-number-and-can-form-kidney-tubule-from-a-single-cell-wrapped-around-itselfEnlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.
When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
Source paper
extracted_from(2022) · Levin, Michael
Neighborhood — ranked by edge-count
Claims (1)
claim
- Extreme example of regulative flexibility.
Communities (2)
community
- Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
- Newt kidney tubules maintain correct lumen diameter despite ploidy-induced cell enlargement via number and wrapping adjustments.
Findings (2)
finding
- Shows multi-scale anatomical homeostasis using different cellular mechanisms.
- From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
Frameworks (1)
framework
- A framework originating from Levin that formalizes how hierarchical biological systems—from cells to tissues to organs—exhibit integrated problem-solving and adaptive plasticity across multiple levels of organization (metabolic, transcriptional, physiological, anatomical). It models system-level behaviors as emergent from competition and cooperation among heterogeneous subunits within composite agents, explaining how goals and regulations scale across biological scales.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.
- Fankhauser 1945 finding on anatomical regulation despite ploidy changes.
- When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
- Engineered polyploid newts with abnormally large cells and extra chromosomes develop normal kidney tubule diameters by switching molecular mechanisms on-the-fly.
Restated by (3)
cosine ≥ 0.90Other entities that say roughly the same thing. May be merge candidates or independent restatements across papers.
- findingNewt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).
- claimNewt kidney tubule cells, when artificially enlarged, can bend a single cell around itself to achieve correct tubule diameter, illustrating top-down control over molecular mechanisms.
- findingSingle newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.