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finding:single-enlarged-cells-can-form-proper-tubules-through-cytoskeletal-bending-aloneSingle enlarged cells can form proper tubules through cytoskeletal bending alone
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extracted_from(2023) · Clawson, Wesley P. · Levin, Michael
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- Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
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- Single newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.finding0.836From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
- Extreme example of regulative flexibility.
- When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
- Shows multi-scale anatomical homeostasis using different cellular mechanisms.
- Extreme case showing the system switches molecular mechanism (cytoskeletal bending vs cell-cell communication) to hit the same anatomical target.
- When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.