finding
active
finding:single-newt-cell-can-wrap-around-itself-to-form-a-kidney-tubule-when-cell-size-is-artificially-increasedSingle newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.
From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
Source paper
extracted_from(2023) · Clawson, Wesley P. · Levin, Michael
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Thinkers (1)
thinker
- G. FankhauserauthoredStudied effects of chromosome number changes on amphibian development, cited for single-cell tubule formation.
Claims (2)
claim
- Extreme example of regulative flexibility.
- Key insight about the nature of evolved systems.
Communities (1)
community
- Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
Findings (2)
finding
- When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Shows multi-scale anatomical homeostasis using different cellular mechanisms.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.
- Fankhauser 1945 finding on anatomical regulation despite ploidy changes.
- Shows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
- Engineered polyploid newts with abnormally large cells and extra chromosomes develop normal kidney tubule diameters by switching molecular mechanisms on-the-fly.
Restated by (3)
cosine ≥ 0.90Other entities that say roughly the same thing. May be merge candidates or independent restatements across papers.
- findingEnlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.
- findingNewt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).
- claimNewt kidney tubule cells, when artificially enlarged, can bend a single cell around itself to achieve correct tubule diameter, illustrating top-down control over molecular mechanisms.