finding
active
finding:single-newt-cell-can-wrap-around-itself-to-form-a-kidney-tubule-when-cell-size-is-artificially-increasedSingle newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.
From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.
Source paper
extracted_from(2023) · Clawson, Wesley P. · Levin, Michael
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Thinkers (1)
thinker
- G. FankhauserauthoredStudied effects of chromosome number changes on amphibian development, cited for single-cell tubule formation.
Claims (1)
claim
- Key insight about the nature of evolved systems.
Communities (1)
community
- Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Extreme example of regulative flexibility.
- Shows multi-scale anatomical homeostasis using different cellular mechanisms.
- When cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- From Fankhauser 1945; illustrates top-down control where large-scale morphology is maintained despite drastically wrong cell size.
- Extreme case showing the system switches molecular mechanism (cytoskeletal bending vs cell-cell communication) to hit the same anatomical target.
- Fankhauser 1945 finding on anatomical regulation despite ploidy changes.
- Polyploid newt kidney tubules use fewer, larger cells to maintain identical organ-level structurefinding0.854Illustrates that anatomical goals are pursued via flexible molecular mechanisms rather than fixed cell-count programs.