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leiden_hybrid_concepts
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community:leiden_hybrid_concepts-run4-c16Tubule size invariance via cell number compensation
Newt kidney tubules maintain correct lumen diameter through cell number adjustment and single-cell self-wrapping in polyploid conditions.
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The papers/notes whose extracted claims & findings make up this cluster.
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Findings (9)
- Enlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Enlarged polyploid cells produce normal-sized kidney tubules by adjusting cell number and using cytoskeletal bendingShows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
- Kidney tubules form correctly despite altered cell size and number
- Newt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).Shows multi-scale anatomical homeostasis using different cellular mechanisms.
- Newt kidney tubule lumen diameter is maintained with fewer, larger cells by switching to a single-cell wrapping mechanismWhen cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- Polyploid Newt Kidney Size Compensation
- Polyploid Newt Kidney Tubule AdaptationEngineered polyploid newts with abnormally large cells and extra chromosomes develop normal kidney tubule diameters by switching molecular mechanisms on-the-fly.
- Single enlarged cells can form proper tubules through cytoskeletal bending alone
- Single newt cell can wrap around itself to form a kidney tubule when cell size is artificially increased.From Fankhauser (1945), demonstrates diverse molecular mechanisms serving a higher-level anatomical specification.