community
active
leiden_hybrid_concepts
label: sonnet
community:leiden_hybrid_concepts-run2-c39Polyploid cell size compensation in tubulogenesis
Newt kidney tubules maintain correct lumen diameter despite ploidy-induced cell enlargement via number and wrapping adjustments.
7 members. Each node is clickable.
Loading graph…
Drawn from 6 sources
The papers/notes whose extracted claims & findings make up this cluster.
- Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms2 members
- Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue1 member
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds1 member
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds1 member
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology1 member
- The collective intelligence of evolution and development1 member
Bridges (1)
Other communities that share members with this one — cross-cutting threads or papers that sit at the seam between two themes.
Findings (7)
- Enlarged newt cells compensate for increased size by adjusting cell number and can form kidney tubule from a single cell wrapped around itself.When cell size was doubled, tubules used fewer cells; when quadrupled, a single cell formed the tubule by cytoskeletal deformation, maintaining correct lumen diameter.
- Enlarged polyploid cells produce normal-sized kidney tubules by adjusting cell number and using cytoskeletal bendingShows diverse molecular mechanisms serve higher-level anatomical specification despite radical changes in cell size and quantity.
- Kidney tubules form correctly despite altered cell size and number
- Newt kidney tubule cells produce correct tubule diameter using fewer cells when cell size is enlarged; a single enlarged cell can loop to achieve the same diameter (Fankhauser 1945).Shows multi-scale anatomical homeostasis using different cellular mechanisms.
- Newt kidney tubule lumen diameter is maintained with fewer, larger cells by switching to a single-cell wrapping mechanismWhen cell size is artificially enlarged, tubule formation adapts by reducing cell count and eventually using cytoskeletal bending within one cell.
- Polyploid Newt Kidney Size Compensation
- Polyploid Newt Kidney Tubule AdaptationEngineered polyploid newts with abnormally large cells and extra chromosomes develop normal kidney tubule diameters by switching molecular mechanisms on-the-fly.