finding
active
finding:artificial-regulation-of-bioelectric-connectivity-can-override-strong-oncogene-expression-to-prevent-tumorigenesis-in-tadpolesArtificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.
Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Source paper
extracted_from(2022) · Levin, Michael
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Claims (1)
claim
- Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.
Communities (4)
community
- Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
- Bioelectric morphogenesis & memorymembers_ofMichael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
- Xenopus studies showing ion channel patterns direct cell collectives toward specific anatomical outcomes independent of genetic or positional cues, led by Michael Levin.
- Cells execute anatomical programs via bioelectric signaling patterns independent of genetic instruction, pioneered by Levin's xenobiology research (2020s).
Concepts (1)
concept
- Cancer as shrinking of the SelfsupportsCancer is interpreted as cells reverting to unicellular selfishness due to loss of gap junctional coupling, shrinking their cognitive boundary.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Shows that restoring bioelectric cohesion can override single-cell goals.
- Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
- The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.810Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
- Co-expression of a hyperpolarizing ion channel prevents tumorigenesis by oncogene p53 in Xenopus tadpolesfinding0.809Bioelectric state modulation can override strong oncogenic mutations, preventing cancer and restoring normal development.
- Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.hypothesis0.805Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
- Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.
Cross-corpus bridges (1)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbHow can bioelectric connectivity be therapeutically manipulated to prevent or reverse cancer metastasis?questions/how-can-bioelectric-connectivity-be-therapeutically-manipulated-to.md0.823