Disconnection from bioelectric tissue networks enables cancer progression; forced bioelectric coupling suppresses cancer phenotypes despite oncogenic mutations.

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• Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.848
  Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
• Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.842
  Shows that restoring bioelectric cohesion can override single-cell goals.
• Artificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.finding0.841
  Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
• The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.840
  Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
• Cancer Suppression via Bioelectric Network Regulationfinding0.824
• Bioelectric networks scale cell computation into anatomical homeostasis and are a mechanism for evolving larger Selves.claim0.816
  Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.
• Cancer can be normalized by reconnecting cells to the electrical network that harnesses them toward adaptive tissue homeostasis.claim0.809
  Proposes a non-toxic cancer treatment strategy.
• Bioelectric state manipulation induces metastatic melanoma or suppresses tumorigenesis in wild-type genetic backgroundfinding0.806
  Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.