Cancer Suppression via Bioelectric Network Regulation

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Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind

(2023) · Levin, Michael

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Bioelectric morphogenesis & anatomical intelligence
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Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
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Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric networks as morphogenetic cognition
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Membrane potential dynamics coordinate multicellular behavior, anatomical memory, and agency scaling across biological levels—studied via melanocyte fate, biofilm oscillations, and xenobotic morphology experiments (Levin et al. 2015–2023).
Bioelectric network control of cellular behavior
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Studies how gap junction-mediated ion gradients and bioelectric patterns regulate cell identity, morphogenesis, and disease states like cancer, pioneered by Levin's group.

Related by similarity (8)

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Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.824
Shows that restoring bioelectric cohesion can override single-cell goals.
Disconnection from bioelectric tissue networks enables cancer progression; forced bioelectric coupling suppresses cancer phenotypes despite oncogenic mutations.finding0.824
Bioelectric Regulationframework0.812
Artificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.finding0.804
Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.801
Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.794
Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
Bioelectric networks scale cell computation into anatomical homeostasis and are a mechanism for evolving larger Selves.claim0.781
Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.
Bioelectric Control of Morphogenesisframework0.778
Framework in which stable voltage patterns in non-neural cells serve as re-writable memory guiding regenerative anatomy, demonstrating software/hardware distinction in biology