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leiden_hybrid_concepts
label: haiku
community:leiden_hybrid_concepts-run4-c2-c0-c4Bioelectric network control of cellular behavior
Studies how gap junction-mediated ion gradients and bioelectric patterns regulate cell identity, morphogenesis, and disease states like cancer, pioneered by Levin's group.
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Findings (3)
- Bioelectric Control of Melanocyte BehaviorSerotonergic signaling from instructor cells controls melanocyte proliferation and invasiveness in frog embryos; bioelectric perturbations produce stochastic organism-level outcomes (70% conversion) while maintaining cell-level concordance.
- Cancer Suppression via Bioelectric Network Regulation
- Disconnection from bioelectric tissue networks enables cancer progression; forced bioelectric coupling suppresses cancer phenotypes despite oncogenic mutations.