hypothesis

active

hypothesis:the-cancer-phenotype-can-be-reverted-by-artificially-managing-the-bioelectric-connections-between-a-cell-and-its-neighbors

The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.

Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Cancer phenotypes can be suppressed by forcing bioelectrical connections among cells, overriding oncogenic mutations (Chernet & Levin 2013).finding0.901
Shows that restoring bioelectric cohesion can override single-cell goals.
Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.888
Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
Disconnection from bioelectric tissue networks enables cancer progression; forced bioelectric coupling suppresses cancer phenotypes despite oncogenic mutations.finding0.840
Cancerous growth can be induced by disruption of electrical coordination signals and reversed by re-establishing them, without genetic changes (Levin 2021a)finding0.833
Empirical finding in developmental biology that supports organismic individuality independent of genetics
Cancer can be normalized by reconnecting cells to the electrical network that harnesses them toward adaptive tissue homeostasis.claim0.830
Proposes a non-toxic cancer treatment strategy.
Manipulating bioelectric states can reprogram target morphology without changing genetics.hypothesis0.819
Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
Artificial regulation of bioelectric connectivity can override strong oncogene expression to prevent tumorigenesis in tadpoles.finding0.810
Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
If cancer represents a shrinkage of the cognitive light cone, then interventions that restore cellular participation in tissue-level information-processing networks should suppress cancer progression.hypothesis0.808
Implicit predictive hypothesis from the cancer-as-cognitive-defect claim, with experimental implications for regenerative medicine

Cross-corpus bridges (8)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

aboutblank_kb
Can cancer be understood and potentially reversed by restoring bioelectric connectivity rather than genetic correction?questions/can-cancer-be-understood-and-potentially-reversed-by.md0.882
aboutblank_kb
How can bioelectric connectivity be therapeutically manipulated to prevent or reverse cancer metastasis?questions/how-can-bioelectric-connectivity-be-therapeutically-manipulated-to.md0.837
aboutblank_kb
Can cancer be understood and treated as a scaling problem of cellular identity?questions/can-cancer-be-understood-and-treated-as-a.md0.825
aboutblank_kb
Can bioelectric reprogramming offer therapeutic approaches to cancer?questions/can-bioelectric-reprogramming-offer-therapeutic-approaches-to-cancer.md0.817
aboutblank_kb
Can gap junctional connectivity be used as a therapeutic target to reverse cancer phenotypes?questions/can-gap-junctional-connectivity-be-used-as-a.md0.809
aboutblank_kb
Can bioelectric code explain cancer as a problem of anatomical homeostasis?questions/can-bioelectric-code-explain-cancer-as-a-problem.md0.805
aboutblank_kb
How can cancer be therapeutically treated without genetic modification by maintaining proper electrical states?questions/how-can-cancer-be-therapeutically-treated-without-genetic.md0.797
aboutblank_kb
Can cells implement reverse central dogma—determining which genes to edit based on physiological state?questions/can-cells-implement-reverse-central-dogmadetermining-which-genes.md0.786