hypothesis
active
hypothesis:manipulating-bioelectric-states-can-reprogram-target-morphology-without-changing-geneticsManipulating bioelectric states can reprogram target morphology without changing genetics.
Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
Source paper
extracted_from(2022) · Michael Levin
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Concepts (1)
concept
- BioelectricityaboutProposed 'cognitive glue' common to both neural and developmental collective intelligence; implemented by ion channels and electrical synapses.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Bioelectric state can reprogram organism morphology and behavior independently of DNA.hypothesis0.900Xenopus evolution experiment showing shape and tissue distribution alone drive morphological change.
- Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.hypothesis0.849Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
- Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.
- The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.819Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
Cross-corpus bridges (12)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbCan morphological identity be computationally defined and manipulated through bioelectric engineering?questions/can-morphological-identity-be-computationally-defined-and-manipulated.md0.864
- aboutblank_kbCan bioelectric target morphologies be read, decoded, and rewritten without changing genetic hardware?questions/can-bioelectric-target-morphologies-be-read-decoded-and.md0.858
- aboutblank_kbHow can bioelectrical interventions be used to reprogram morphology and achieve synthetic biology goals?questions/how-can-bioelectrical-interventions-be-used-to-reprogram.md0.853
- aboutblank_kbHow do cells compute and maintain anatomical target states during regeneration despite genetic degeneracy and noise?questions/how-do-cells-compute-and-maintain-anatomical-target.md0.851
- aboutblank_kbHow can bioelectric pattern memories be edited or rewritten without changing the genome?questions/how-can-bioelectric-pattern-memories-be-edited-or.md0.840
- aboutblank_kbCan bioelectric reprogramming offer therapeutic approaches to cancer?questions/can-bioelectric-reprogramming-offer-therapeutic-approaches-to-cancer.md0.839
- aboutblank_kbCan anatomical homeostasis and morphological goal-directedness be reversed through bioelectric reprogramming?questions/can-anatomical-homeostasis-and-morphological-goaldirectedness-be-reversed.md0.833
- aboutblank_kbCan bioelectric manipulation enable predictive control over morphogenesis without genetic changes?questions/can-bioelectric-manipulation-enable-predictive-control-over-morphogenesis.md0.829
- aboutblank_kbHow can physiological experience rewrite anatomical memories encoded in bioelectric states without genetic modification?questions/how-can-physiological-experience-rewrite-anatomical-memories-encoded.md0.828
- aboutblank_kbCan regenerative medicine and bioengineering leverage multiscale bioelectric control to rationally reprogram body form and treat disease?questions/can-regenerative-medicine-and-bioengineering-leverage-multiscale-bioelectric.md0.825
- aboutblank_kbSynthetic Morphologyframeworks/synthetic-morphology.md0.822
- aboutblank_kbWhat molecular mechanisms enable false pattern memories to be rewritten into genetically-specified electrical circuits?questions/what-molecular-mechanisms-enable-false-pattern-memories-to.md0.822