hypothesis
active
hypothesis:bioelectric-states-can-serve-as-master-regulators-of-organogenesis-bypassing-the-need-to-manipulate-downstream-genetic-cascadesBioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.
Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
Source paper
extracted_from(2022) · Michael Levin
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Findings (1)
finding
- Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.
Related by similarity (8)
cosine ≥ 0.65 · no typed edgeEntities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.
- Bioelectric state can reprogram organism morphology and behavior independently of DNA.hypothesis0.853Xenopus evolution experiment showing shape and tissue distribution alone drive morphological change.
- Manipulating bioelectric states can reprogram target morphology without changing genetics.hypothesis0.849Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
- Posits deep evolutionary continuity between somatic pattern control and neural cognition.
- Developmental bioelectricity is proposed as a tractable entry point to understand the informational architecture of collective intelligence in morphogenesis.
- Co-injection of a hyperpolarizing ion channel with oncogene prevented tumor formation and restored normal tissue, showing bioelectric control over genetic state.
Cross-corpus bridges (12)
same_concept_as · Nomic cosineExternal markdown files that talk about the same concept as this entity.
- aboutblank_kbHow do simple bioelectric trigger states scale up into complex, organ-level anatomical control without micromanagement of component cells?questions/how-do-simple-bioelectric-trigger-states-scale-up.md0.850
- aboutblank_kbWhat role do bioelectric signals play in encoding morphogenetic information independent of genetics?questions/what-role-do-bioelectric-signals-play-in-encoding.md0.847
- aboutblank_kbHow do cells compute and maintain anatomical target states during regeneration despite genetic degeneracy and noise?questions/how-do-cells-compute-and-maintain-anatomical-target.md0.842
- aboutblank_kbHow can bioelectric states in multicellular systems encode and execute complex behavioral goals?questions/how-can-bioelectric-states-in-multicellular-systems-encode.md0.835
- aboutblank_kbCan bioelectric systems be used to rationally control morphogenesis and treat cancer?questions/can-bioelectric-systems-be-used-to-rationally-control.md0.835
- aboutblank_kbHow can physiological experience rewrite anatomical memories encoded in bioelectric states without genetic modification?questions/how-can-physiological-experience-rewrite-anatomical-memories-encoded.md0.833
- aboutblank_kbBioelectric Regulationframeworks/bioelectric-regulation.md0.832
- aboutblank_kbHow can bioelectric states encode and specify complex body plans independently of genetic information?questions/how-can-bioelectric-states-encode-and-specify-complex.md0.827
- aboutblank_kbCan morphological identity be computationally defined and manipulated through bioelectric engineering?questions/can-morphological-identity-be-computationally-defined-and-manipulated.md0.825
- aboutblank_kbHow can bioelectric states represent future morphological goals rather than current anatomy?questions/how-can-bioelectric-states-represent-future-morphological-goals.md0.822
- aboutblank_kbWhat role do bioelectric patterns play in morphogenesis and regeneration?questions/what-role-do-bioelectric-patterns-play-in-morphogenesis.md0.822
- aboutblank_kbHow can the same cellular collective with identical genome produce radically different anatomical outcomes based purely on bioelectric state?questions/how-can-the-same-cellular-collective-with-identical.md0.819