finding

active

finding:misexpression-of-a-single-ion-channel-induces-complete-ectopic-eye-formation-in-gut-endoderm-of-vertebrates

Misexpression of a single ion channel induces complete ectopic eye formation in gut endoderm of vertebrates.

Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Levin, Michael

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Hypotheses (1)

hypothesis

Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.
supports
Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.

Communities (4)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
members_of
Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric code and anatomical goal-setting
members_of
Xenopus studies showing ion channel patterns direct cell collectives toward specific anatomical outcomes independent of genetic or positional cues, led by Michael Levin.
Bioelectric code for ectopic organogenesis
members_of
Ion channel modulation induces ectopic organ formation through bioelectric signals, pioneered by Levin's xenopus experiments circa 2018-2021.

Concepts (1)

concept

Bioelectricity
supports
Proposed 'cognitive glue' common to both neural and developmental collective intelligence; implemented by ion channels and electrical synapses.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Ectopic Eye Induction via Ion Channel Modulationfinding0.837
Ion channel-modified cells recruit neighbors to complete eye organogenesisfinding0.814
Ectopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.
Voltage-induced ectopic eye formation in tadpolesfinding0.798
A simple voltage state imposed on somatic cells can induce them to build a complete vertebrate eye.finding0.792
Pai et al. 2012 finding on bioelectric control of eye formation.
Ectopic Eye Formation via Bioelectric Signalingfinding0.789
Misexpression of potassium channels in frog tadpole gut or tail induces formation of complete, functional eyes in ectopic locations; demonstrates that morphogenetic modules can be triggered by high-level bioelectric signals without specifying molecular details.
Ectopic eyes formed in frog embryo tails still function; eye primordia cells succeed in forming an eye, optic nerve, and correct neural connections despite abnormal spatial context.finding0.788
Tadpoles with ectopic eyes on tail can see and integrate sensory input from aberrant locationfinding0.767
Demonstrates neural plasticity: brain adapts behavioral programs to sensory input from abnormal anatomical locations within single organism lifetime.
Ectopic eyes on tadpole tail provide functional vision despite connecting only to spinal cord or peripheral tissue.finding0.762
Result from Blackiston & Levin 2013: sensory data from displaced eyes can be used for learned behavior without evolutionary adaptation.