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leiden_hybrid_concepts
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community:leiden_hybrid_concepts-run4-c2-c1-c0Bioelectric code for ectopic organogenesis
Ion channel modulation induces ectopic organ formation through bioelectric signals, pioneered by Levin's xenopus experiments circa 2018-2021.
4 members. Each node is clickable.
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The papers/notes whose extracted claims & findings make up this cluster.
- Darwin's agential materials: evolutionary implications of multiscale competency in developmental biology2 members
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds1 member
- Collective intelligence: A unifying concept for integrating biology across scales and substrates1 member
Bridges (3)
Other communities that share members with this one — cross-cutting threads or papers that sit at the seam between two themes.
Findings (4)
- Ectopic Eye Formation via Bioelectric SignalingMisexpression of potassium channels in frog tadpole gut or tail induces formation of complete, functional eyes in ectopic locations; demonstrates that morphogenetic modules can be triggered by high-level bioelectric signals without specifying molecular details.
- Ectopic Eye Induction via Ion Channel Modulation
- Ion channel-modified cells recruit neighbors to complete eye organogenesisEctopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.
- Misexpression of a single ion channel induces complete ectopic eye formation in gut endoderm of vertebrates.Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.