finding

active

finding:ion-channel-modified-cells-recruit-neighbors-to-complete-eye-organogenesis

Ion channel-modified cells recruit neighbors to complete eye organogenesis

Ectopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.

Source paper

extracted_from

Collective intelligence: A unifying concept for integrating biology across scales and substrates

(2024) · Patrick McMillen · Michael Levin

Neighborhood — ranked by edge-count

Claims (1)

claim

Collective intelligence exists on a spectrum across biology from cells to organisms
supports
Authors argue no sharp distinction exists between familiar animal cognition and collective behavior in cells/tissues; same principles apply across scales and substrates.

Communities (4)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
members_of
Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric code and anatomical goal-setting
members_of
Xenopus studies showing ion channel patterns direct cell collectives toward specific anatomical outcomes independent of genetic or positional cues, led by Michael Levin.
Bioelectric code for ectopic organogenesis
members_of
Ion channel modulation induces ectopic organ formation through bioelectric signals, pioneered by Levin's xenopus experiments circa 2018-2021.

Methods (1)

method

Ion Channel Misexpression and Chemical Activation
supports
Experimental technique to induce bioelectric state changes and measure consequences for collective decision-making (morphogenesis, cancer, organ formation).

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Ectopic Eye Induction via Ion Channel Modulationfinding0.820
Misexpression of a single ion channel induces complete ectopic eye formation in gut endoderm of vertebrates.finding0.814
Setting cells to an eye-like bioelectric prepattern via ion channel manipulation creates fully formed eyes in abnormal locations, where the master gene Pax6 is insufficient.
When a subset of cells is given a morphogenetic goal (e.g., build an eye), they autonomously recruit unmodified neighbors to complete the structure, showing modular competency.claim0.798
Principle of top-down control.
A simple voltage state imposed on somatic cells can induce them to build a complete vertebrate eye.finding0.770
Pai et al. 2012 finding on bioelectric control of eye formation.
Most of Crump et al.'s other criteria are met by non-neural morphogenetic agents via a simple pivot of terms to 'electrically active cell'.claim0.760
Generalization of the criteria beyond neurons.
Ion channels enable electrical communication in bacterial communities (Prindle et al. 2015)finding0.759
Bacteria use similar bioelectric mechanisms to metazoans to coordinate collective behavior.
Genetic, chemical, and optical manipulation of ion channels and gap junctionsmethod0.758
Target morphology shifts occur despite the fact that all of the individual cells have unaltered normal genomes, showing that competent subunits can be pushed to implement diverse organism-scale goals by physiological signals.claim0.756
Highlights the non-genetic control of large-scale anatomy.