Genetic, chemical, and optical manipulation of ion channels and gap junctions

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• gap junction manipulationmethod0.788
  Using drugs or genetic tools to open/close gap junctions and probe bioelectric networks in development.
• Ion Channels and Pumpsmethod0.775
  Cellular machinery controlling resting potential and voltage dynamics; manipulable via drugs or optogenetics to modulate morphogenetic outcomes.
• Gap junctions provide an 'owner wiping property' for signaling molecules, leading to partial erasure of individual identity for cells in a network and enabling a higher-order emergent collective.claim0.771
  Mechanistic claim for how collectives scale.
• Ion Channel Misexpression and Chemical Activationmethod0.763
  Experimental technique to induce bioelectric state changes and measure consequences for collective decision-making (morphogenesis, cancer, organ formation).
• Gap junctional coupling wipes ownership information on signaling molecules, enabling the formation of multicellular Selves.claim0.762
  Because cells cannot distinguish internally generated signals from those arriving through GJs, they share memories and bind into a larger agent.
• Gap junctions provide a dynamic that massively augments cooperative interactions and scales cognitive boundary.claim0.762
  Explains the biological mechanism for cognitive scaling.
• Ion channel-modified cells recruit neighbors to complete eye organogenesisfinding0.758
  Ectopic eyes induced by ion channel misexpression; if few cells injected, they recruit unmanipulated neighbors to produce normal-sized eyes—collective recruitment competency.
• Ion channels enable electrical communication in bacterial communities (Prindle et al. 2015)finding0.757
  Bacteria use similar bioelectric mechanisms to metazoans to coordinate collective behavior.