hypothesis

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hypothesis:bioelectric-state-can-reprogram-organism-morphology-and-behavior-independently-of-dna

Bioelectric state can reprogram organism morphology and behavior independently of DNA.

Xenopus evolution experiment showing shape and tissue distribution alone drive morphological change.

Source paper

extracted_from

Living Things Are Not (20th Century) Machines: Updating Mechanism Metaphors in Light of the Modern Science of Machine Behavior

(2021) · Joshua Bongard · Michael Levin

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Claims (1)

claim

DNA, bioelectric fields, and specialized AI hardware blur hardware/software distinctions.
supports
Biological and technological systems increasingly manifest properties of both hardware and software simultaneously.

Artifacts (1)

artifact

Xenopus laevis Derived Organisms
supports
Evolved organism composed of frog cells achieving novel self-motility through non-neural control.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Manipulating bioelectric states can reprogram target morphology without changing genetics.hypothesis0.900
Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.hypothesis0.853
Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
Bioelectric state manipulation induces metastatic melanoma or suppresses tumorigenesis in wild-type genetic backgroundfinding0.811
Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.
Developmental bioelectricity provides a tractable entrypoint into the informational architecture of the collective intelligence of morphogenesis.claim0.803
Bioelectric patterns serve as re-writable pattern memories for anatomical homeostasis.
The cancer phenotype can be reverted by artificially managing the bioelectric connections between a cell and its neighbors.hypothesis0.803
Predicts that restoring gap junctional coupling or appropriate Vmem can normalize oncogene-expressing cells.
Can Bioelectric Reprogramming Offer Therapeutic Approaches To Cancerquestion0.802
How Can Bioelectric States Represent Future Morphological Goalsquestion0.801
How Can Bioelectric States In Multicellular Systems Encodequestion0.801

Cross-corpus bridges (12)

same_concept_as · Nomic cosine

External markdown files that talk about the same concept as this entity.

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Can morphological identity be computationally defined and manipulated through bioelectric engineering?questions/can-morphological-identity-be-computationally-defined-and-manipulated.md0.856
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How can physiological experience rewrite anatomical memories encoded in bioelectric states without genetic modification?questions/how-can-physiological-experience-rewrite-anatomical-memories-encoded.md0.841
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How can bioelectrical interventions be used to reprogram morphology and achieve synthetic biology goals?questions/how-can-bioelectrical-interventions-be-used-to-reprogram.md0.839
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What is the nature of the bioelectric code that encodes target morphology, and how is it distinct from genetic information?questions/what-is-the-nature-of-the-bioelectric-code.md0.838
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What molecular mechanisms enable false pattern memories to be rewritten into genetically-specified electrical circuits?questions/what-molecular-mechanisms-enable-false-pattern-memories-to.md0.838
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Can bioelectric target morphologies be read, decoded, and rewritten without changing genetic hardware?questions/can-bioelectric-target-morphologies-be-read-decoded-and.md0.838
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How can the same genome produce different numbers of heads depending on bioelectric state?questions/how-can-the-same-genome-produce-different-numbers.md0.830
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How do cells compute and maintain anatomical target states during regeneration despite genetic degeneracy and noise?questions/how-do-cells-compute-and-maintain-anatomical-target.md0.830
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How do bioelectric patterns encode morphological information and control development independent of genetic sequence?questions/how-do-bioelectric-patterns-encode-morphological-information-and.md0.830
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How can bioelectric states encode and specify complex body plans independently of genetic information?questions/how-can-bioelectric-states-encode-and-specify-complex.md0.827
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How can bioelectric states in multicellular systems encode and execute complex behavioral goals?questions/how-can-bioelectric-states-in-multicellular-systems-encode.md0.824
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How can the same cellular collective with identical genome produce radically different anatomical outcomes based purely on bioelectric state?questions/how-can-the-same-cellular-collective-with-identical.md0.823