finding

active

finding:bioelectric-state-manipulation-induces-metastatic-melanoma-or-suppresses-tumorigenesis-in-wild-type-genetic-background

Bioelectric state manipulation induces metastatic melanoma or suppresses tumorigenesis in wild-type genetic background

Depolarization of melanocytes converts them to a metastatic state; conversely, hyperpolarization prevents tumor formation even with oncogene expression.

Source paper

extracted_from

Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds

(2022) · Michael Levin

Neighborhood — ranked by edge-count

Claims (1)

claim

Cancer is a breakdown of the collective intelligence of tissues, a shrinking of the Self boundary due to gap junction closure.
supports
Frames metastasis as cells reverting to unicellular goals, treatable by restoring bioelectric connectivity.

Communities (3)

community

Bioelectric morphogenesis & anatomical intelligence
members_of
Levin-led research showing bioelectric signals encode and control anatomical goal states in living systems.
Bioelectric morphogenesis & memory
members_of
Michael Levin's research on bioelectric signaling controlling anatomical goals, regeneration, and cancer.
Bioelectric control of cancer and morphogenesis
members_of
Using ion channel manipulation and bioelectric state to suppress tumorigenesis and override oncogenic pathways, pioneered by Michael Levin's group.

Related by similarity (8)

cosine ≥ 0.65 · no typed edge

Entities in the same semantic neighborhood but without a typed relation to this one — candidates for new edges or unrecognized duplicates.

Bioelectric depolarization induces melanoma transformationfinding0.834
Experimentally validated prediction: depolarizing specific cell populations in normal tadpoles induces metastatic melanoma transformation, demonstrating causal role of bioelectric communication.
Manipulating bioelectric states can reprogram target morphology without changing genetics.hypothesis0.834
Demonstrated by inducing two-headed planaria via ion channel drugs; predicts cancer normalization.
Suppression of cancer phenotypes despite strong oncogenic mutations via forced bioelectrical connections among cells, overriding single-cell goals with morphogenetic ones.finding0.814
Empirical demonstration that bioelectric network topology, not genetic state, determines whether cellular optimization occurs at single-cell (cancer) vs. organ level.
Bioelectric state can reprogram organism morphology and behavior independently of DNA.hypothesis0.811
Xenopus evolution experiment showing shape and tissue distribution alone drive morphological change.
Disconnection from bioelectric tissue networks enables cancer progression; forced bioelectric coupling suppresses cancer phenotypes despite oncogenic mutations.finding0.806
Can Bioelectric Manipulation Enable Predictive Control Over Morphogenesisquestion0.805
Bioelectric states can serve as master regulators of organogenesis, bypassing the need to manipulate downstream genetic cascades.hypothesis0.804
Predicts that simple voltage changes can trigger complex modular morphogenetic programs, useful for regenerative medicine.
Bioelectric Control of Melanocyte Behaviorfinding0.804
Serotonergic signaling from instructor cells controls melanocyte proliferation and invasiveness in frog embryos; bioelectric perturbations produce stochastic organism-level outcomes (70% conversion) while maintaining cell-level concordance.